Plasmodium berghei: antiparasitic effects of orally administered hypoestoxide in mice.
作者： Emmanuel A. Ojo-Amaize , Emeka J. Nchekwube , Howard B. Cottam , Olusola A. Oyemade , Akinbo A. Adesomoju
DOI: 10.1016/J.EXPPARA.2007.04.012
关键词:
摘要: Hypoestoxide (HE) is a diterpene isolated from Hypoestes rosea (Acanthaceae), plant indigenous to Nigeria. Previous studies demonstrated that HE exhibited potent anti-inflammatory and anti-cancer activities in well established animal models but weak vitro both the anti-inflammation screening systems. We now report similar observation vivo systems for antimalarial activity. The results indicate while exhibits relatively activity (IC(50) = 10 microM versus 0.11 chloroquine) against different strains of cultured P. falciparum parasites, dose required reduce parasitemia by 90% Plasmodium berghei-infected mice, much lower than standard antimalaria drugs (SD(90) 250 microg/kg 5mg/kg chloroquine). Furthermore, doses were more effective higher inhibiting parasite development. implications these findings are discussed.
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sci-hub.se 参考文章(14)
Michael Walther, John Woodruff, Fanny Edele, David Jeffries, Jon E. Tongren, Elizabeth King, Laura Andrews, Philip Bejon, Sarah C. Gilbert, Joseph B. De Souza, Robert Sinden, Adrian V. S. Hill, Eleanor M. Riley, Innate Immune Responses to Human Malaria: Heterogeneous Cytokine Responses to Blood-Stage Plasmodium falciparum Correlate with Parasitological and Clinical Outcomes Journal of Immunology. ,vol. 177, pp. 5736- 5745 ,(2006) , 10.4049/JIMMUNOL.177.8.5736
Olusola A. Oyemade, Emeka J. Nchekwube, Pascal Verdier-Pinard, Lorenzo Leoni, Emmanuel A. Ojo-Amaize, Ernest Hamel, Judith A. Varner, Akinbo A. Adesomoju, Howard B. Cottam, Ruoli Bai, Joseph I. Okogun, Vellalore N. Kakkanaiah, Hypoestoxide, a natural nonmutagenic diterpenoid with antiangiogenic and antitumor activity: possible mechanisms of action. Cancer Research. ,vol. 62, pp. 4007- 4014 ,(2002)
Thomas M. Devlin, Textbook of biochemistry: With clinical correlations ,(1982)
Emmanuel A. Ojo-Amaize, Pankaj Kapahi, Vellalore N. Kakkanaiah, Takayuki Takahashi, Tali Shalom-Barak, Howard B. Cottam, Akinbo A. Adesomoju, Emeka J. Nchekwube, Olusola A. Oyemade, Michael Karin, Joseph I. Okogun, Hypoestoxide, a Novel Anti-inflammatory Natural Diterpene, Inhibits the Activity of IκB Kinase Cellular Immunology. ,vol. 209, pp. 149- 157 ,(2001) , 10.1006/CIMM.2001.1798
Michael P. Cava, Akinbo A. Adesomoju, Joseph I. Okogun, Patrick J. Carroll, Hypoestoxide, a new diterpene from hypoestes rosea (Acanthaceae) Heterocycles. ,vol. 20, pp. 2125- 2128 ,(1983) , 10.3987/R-1983-11-2125
Karina RB Bastos, Renato Barboza, Rosa M Elias, Luiz R Sardinha, Marcos G Grisotto, Cláudio RF Marinho, Gustavo P Amarante-Mendes, José M Alvarez, Maria Regina D'Império Lima, None, Impaired macrophage responses may contribute to exacerbation of blood-stage Plasmodium chabaudi chabaudi malaria in interleukin-12-deficient mice Journal of Interferon and Cytokine Research. ,vol. 22, pp. 1191- 1199 ,(2002) , 10.1089/10799900260475713
Hugues Matile, Robert G. Ridley, Jawad Alzeer, Jacques Chollet, Ingrid Heinze-Krauss, Christian Hubschwerlen, Phenyl β-Methoxyacrylates: A New Antimalarial Pharmacophore Journal of Medicinal Chemistry. ,vol. 43, pp. 560- 568 ,(2000) , 10.1021/JM990002Y
M.A. Murado, J.A. Vázquez, The notion of hormesis and the dose–response theory: A unified approach Journal of Theoretical Biology. ,vol. 244, pp. 489- 499 ,(2007) , 10.1016/J.JTBI.2006.09.002
Jed E Olson, Garson K Lee, Andrey Semenov, Philip J Rosenthal, Antimalarial effects in mice of orally administered peptidyl cysteine protease inhibitors Bioorganic & Medicinal Chemistry. ,vol. 7, pp. 633- 638 ,(1999) , 10.1016/S0968-0896(99)00004-8
Hagai Ginsburg, Oleg Famin, Jianmin Zhang, Miriam Krugliak, Inhibition of glutathione-dependent degradation of heme by chloroquine and amodiaquine as a possible basis for their antimalarial mode of action. Biochemical Pharmacology. ,vol. 56, pp. 1305- 1313 ,(1998) , 10.1016/S0006-2952(98)00184-1