Open-channel chip-based solid-phase extraction combined with inductively coupled plasma-mass spectrometry for online determination of trace elements in volume-limited saline samples

摘要: Abstract In this study, we used an automated online chip-based solid-phase extraction (SPE)–inductively coupled plasma-mass spectrometry (ICP-MS) system for analyzing trace elements in small-volume saline samples (∼15 μL). The proposed method involved the adsorption of metal ions interior a functionalized poly(methyl methacrylate) (PMMA) channel order to separate these from matrices. transition was presumably dominated by surface complexation between carboxylate moieties PMMA and ions, which facilitated formation metal–carboxylate complexes. components analytical simultaneous detection multiple metals microdialysis (MD) sampling, established SPE procedure, ICP-MS. SPE–ICP-MS hyphenated optimized, then, reliability further confirmed using it analyze certified reference materials—SRM 2670 (human urine) SRM 1643e (artificial water). satisfactory results indicated that on-chip device could be readily as interface coupling MD probe with ICP-MS system. dramatically reduced consumption chemicals “hands-on” manipulations enabled realization simplified relatively clean procedure extremely low limits range 5.86–76.91 ng L−1 detecting Mn, Co, Ni, Cu, Pb 15-μL effectiveness MD–chip-based technique continuous monitoring simulated biological also demonstrated. To best our knowledge, is first paper report direct exploitation chip adsorbent sample pretreatment preconcentration prior measurement.