Morphological and functional changes after benzalkonium chloride treatment of the small intestinal Thiry-Vella loop in rats.

摘要: The aim of this work was to study the effects benzalkonium chloride (BAC) treatment on small intestine and its functioning in rats surgically prepared with Thiry-Vella intestinal loop. loops were treated either BAC, which ablated much myenteric plexus extrinsic innervation, or physiological saline (SAL). In vivo drinking experiments performed examine effect fluid intake behavioral indices distending loop a balloon. Spontaneous motility changes induced by acetylcholine (ACh) histamine (His) studied isolated stripes vitro. Finally, samples from examined histologically. Though reduction cell number less than expected no differences thickness muscular layer between two groups observed, BAC altered pattern spontaneous activity also sensitivity ACh His stripes. distension SAL-treated reduced produced signs aversivity; these absent BAC-treated group. Our results show that despite degree ablation those obtained others, can be used mechanisms underlying enteral stimuli behavior.