Hemocompatibility of heparin-coated surfaces and the role of selective plasma protein adsorption.
作者： Norbert Weber , Hans P Wendel , Gerhard Ziemer
DOI: 10.1016/S0142-9612(01)00122-3
关键词:
摘要: Although several studies have shown that heparin-coated surfaces reduce the activation of both the complement system and the coagulation system, there is still inadequate understanding of the factors initiating and controlling blood activation at these surfaces. We investigated the adsorption profile of 12 common plasma proteins (and the platelet receptor CD41) to a heparin coating (Carmeda BioActive surface (CBAS)) compared to uncoated controls (PVC) by using an in vitro whole blood Chandler-Loop model. Surface bound …
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