The Cost Effectiveness of Therapeutic and Prophylactic Leukocyte Transfusion

作者: Marc S. Rosenshein , Vernon T. Farewell , Thomas H. Price , Eric B. Larson , David C. Dale

DOI: 10.1056/NEJM198005083021904

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摘要: We analyzed the cost effectiveness of leukocyte transfusion in preventing death from infection during intensive chemotherapy for acute leukemia. Effectiveness was estimated with an odds-ratio analysis based on published results controlled studies therapeutic and prophylactic transfusion. Cost estimates were blood-bank charges throughout country. Calculations suggest that might prevent 50 to 75 per cent early deaths infection. Therapeutic would add approximately 10.9 hospital bill average leukemic patient $17.7 million annually nationwide. Prophylactic 35.2 $57.8 annually. Mean cost-effectiveness ratios $14,982 life-year $35,020 $50,029 The additional achieved rather than tran...

参考文章(16)
D. Crowther, C. J. T. Bateman, C. P. Vartan, J. M. A. Whitehouse, J. S. Malpas, G. H. Fairley, R. B. Scott, Combination Chemotherapy using L-Asparaginase, Daunorubicin, and Cytosine Arabinoside in Adults with Acute Myelogenous Leukaemia BMJ. ,vol. 4, pp. 513- 517 ,(1970) , 10.1136/BMJ.4.5734.513
Marc J. Gurwith, James L. Brunton, Beverley A. Lank, Allan R. Ronald, Godfrey K.M. Harding, Granulocytopenia in hospitalized patients The American Journal of Medicine. ,vol. 64, pp. 121- 126 ,(1978) , 10.1016/0002-9343(78)90187-0
RobertPeter Gale, MartinJ. Cline, HIGH REMISSION-INDUCTION RATE IN ACUTE MYELOID LEUKÆMIA The Lancet. ,vol. 309, pp. 497- 499 ,(1977) , 10.1016/S0140-6736(77)91366-6
Gerald P. Bodey, Victorio Rodriguez, Hui-Yen Chang, Gino Narboni, Fever and infection in leukemic patients. A study of 494 consecutive patients Cancer. ,vol. 41, pp. 1610- 1622 ,(1978) , 10.1002/1097-0142(197804)41:4<1610::AID-CNCR2820410452>3.0.CO;2-B
Paul V. Stange, Andrew T. Sumner, Predicting treatment costs and life expectancy for end-stage renal disease. The New England Journal of Medicine. ,vol. 298, pp. 372- 378 ,(1978) , 10.1056/NEJM197802162980705
Donald J. Higby, Jerome W. Yates, Edward S. Henderson, James F. Holland, Filtration Leukapheresis for Granulocyte Transfusion Therapy New England Journal of Medicine. ,vol. 292, pp. 761- 766 ,(1975) , 10.1056/NEJM197504102921501
Herbert E. Klarman, Jhon O??S. Francis, Gerald D. Rosenthal, Cost Effectiveness Analysis Applied to the Treatment of Chronic Renal Disease Medical Care. ,vol. 6, pp. 48- 54 ,(1968) , 10.1097/00005650-196801000-00005
Roger H. Herzig, Geoffrey P. Herzig, Robert G. Graw, Malcolm I. Bull, Karyl K. Ray, Successful Granulocyte Transfusion Therapy for Gram-Negative Septicemia New England Journal of Medicine. ,vol. 296, pp. 701- 705 ,(1977) , 10.1056/NEJM197703312961301
William R. Vogler, Elliott F. Winton, A controlled study of the efficacy of granulocyte transfusions in patients with neutropenia The American Journal of Medicine. ,vol. 63, pp. 548- 555 ,(1977) , 10.1016/0002-9343(77)90200-5
D. R. Cox, E. J. Snell, analysis of binary data ,(1970)