The effects of amlodipine and platelet rich plasma on bone healing in rats.
作者： Yusuf Atalay , Fatih Bozkurt , Yucel Gonul , Omer Cakmak , Kamil Serkan Agacayak
DOI: 10.2147/DDDT.S80778
关键词:
摘要: AIM The aim of this study was to evaluate the effects calcium channel blocker (CCB) amlodipine (AML), platelet rich plasma (PRP), and a mixture both materials on bone healing. MATERIALS AND METHODS Fifty-six male Wistar rats were randomly divided into four groups: group A, tibia defect model with no treatment; B, treated AML, 0.04 mg daily by oral gavage; C, local PRP; D, PRP gavage. RESULTS At day 21, healing significantly better in groups C D compared A (P 0.05). 30, B showed statistically significant difference (P>0.05) but than 0.05), AML + increased ALP activity (P<0.05). CONCLUSION It can be concluded that had neither positive nor negative effect healing, when used combination PRP, it may beneficial.
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sci-hub.se 参考文章(57)
A K Garg, The use of platelet-rich plasma to enhance the success of bone grafts around dental implants. Dental implantology update. ,vol. 11, pp. 17- 21 ,(2000)
Stuart J Froum, Sang-Choon Cho, Dennis P Tarnow, Stephen S Wallace, Effect of platelet-rich plasma on bone growth and osseointegration in human maxillary sinus grafts: three bilateral case reports. International Journal of Periodontics & Restorative Dentistry. ,vol. 22, pp. 45- 53 ,(2002)
Lionel H. Opie, Calcium antagonists and cardiovascular disease Raven Press. ,(1984)
Arnold M. Katz, W. David Hager, Frank C. Messineo, Achilles J. Pappano, Cellular Actions and Pharmacology of the Calcium Channel Blocking Drugs The American Journal of Medicine. ,vol. 77, pp. 2- 10 ,(1984) , 10.1016/S0002-9343(84)80078-9
Mehmet Akif Eskan, Henry Greenwell, Theoretical and Clinical Considerations for Autologous Blood Preparations: Platelet-Rich Plasma, Fibrin Sealants, and Plasma-Rich Growth Factors Clinical advances in periodontics. ,vol. 1, pp. 142- 153 ,(2011) , 10.1902/CAP.2011.110034
Tie-Lou Chen, Hui-Jie Lu, Guo-qin Liu, Da-Hai Tang, Xin-hai Zhang, Zhu-Lin Pan, Shi-Feng Wang, Qing-fu Zhang, Effect of autologous platelet-rich plasma in combination with bovine porous bone mineral and bio-guide membrane on bone regeneration in mandible bicortical bony defects. Journal of Craniofacial Surgery. ,vol. 25, pp. 215- 223 ,(2014) , 10.1097/SCS.0000000000000420
Rogério Bonfante Moraes, Luciana Corrêa, João Gualberto Cerqueira Luz, Adverse effects of the amlodipine on bone healing of the mandibular fracture: an experimental study in rats Oral and Maxillofacial Surgery. ,vol. 15, pp. 93- 101 ,(2011) , 10.1007/S10006-010-0237-6
Beatriz Civantos, Amaya Aleixandre, Blood pressure and α-vascular reactivity in hypertensive rats treated with amlodipine and dietary Ca European Journal of Pharmacology. ,vol. 489, pp. 101- 110 ,(2004) , 10.1016/J.EJPHAR.2004.02.032
Hideo Shimizu, Hironori Nakagami, Natsuki Yasumasa, Osako Kiomy Mariana, Mariko Kyutoku, Hiroshi Koriyama, Futoshi Nakagami, Munehisa Shimamura, Hiromi Rakugi, Ryuichi Morishita, Cilnidipine, but not amlodipine, ameliorates osteoporosis in ovariectomized hypertensive rats through inhibition of the N-type calcium channel. Hypertension Research. ,vol. 35, pp. 77- 81 ,(2012) , 10.1038/HR.2011.143
Linwei Chen, Xiaobo Yang, Gao Huang, Dianwen Song, Xue-Shi Ye, Huazi Xu, Wanli Li, Platelet-rich plasma promotes healing of osteoporotic fractures. Orthopedics. ,vol. 36, ,(2013) , 10.3928/01477447-20130523-10