Multidrug resistance gene 1 C1236T polymorphism and susceptibility to leukemia: A meta-analysis

摘要: Several studies have investigated the association between multidrug resistance gene (MDR1) C1236T polymorphism and leukemia risk, however, these published yielded conflicting results. Thus, present study carried out a meta-analysis to provide more precise estimate of effect this on susceptibility leukemia. The case-control regarding MDR1 risk were included following computerized search PubMed, Elsevier, Cochrane Library, China National Knowledge Infrastructure Wanfang Database. Either fixed- or random-effects models applied calculate combined odds ratios (ORs) 95% confidence intervals (CIs) by RevMan 5.2 software. Seven studies, including 846 cases 1,523 controls, in meta-analysis. results indicated that there was no significant overall comparisons all four genetic (CT vs. CC: OR, 1.31, CI, 0.89-1.91, P=0.17; TT 2.16, 0.99-4.70, P=0.05; CC+CT: 1.72, 0.91-3.25, P=0.09; CT+TT 1.57, 0.96-2.56, P=0.07). In subgroup analysis according specific ethnicity, age type leukemia, found adult (CT+TT 2.77, 1.05-7.31, P=0.04) chronic myeloid 1.71, 1.05-2.80, P=0.03). No publication bias detected funnel plot. Therefore, may contribute Furthe well-designed based larger sample sizes are required validate findings.