Insulin-like growth factor-1 and soluble FMS-like tyrosine kinase-1 prospectively predict cancelled IVF cycles

摘要: PURPOSE To identify biomarkers that prospectively predict IVF cycle cancellation. METHODS In this prospective study, sera were obtained prior to any intervention, from women about undergo an cycle. The assayed by ELISA for levels of insulin-like growth factor (IGF)-1, IGF-2, IGF binding protein (BP)-1, and soluble fms-like tyrosine kinase (sFLT-1). cancellation or progression the was subsequently chart review. Associations between serum components outcome analyzed Mann-Whitney test. Receiver operator curves constructed evaluate strength correlations cancellation, as assessed area under curve (AUC). RESULTS A total 205 included. Twenty-seven (13.2%) cancellations due poor response recorded. Women with a cancelled had reduced anti-Mullerian hormone (AMH) values (p < 0.001) antral follicle count = 0.003). There no significant differences two groups regard age BMI. Median concentrations IGF-1 sFLT-1 elevated in whose cycles compared those ongoing 0.015 p 0.001, respectively); AUC 0.67 0.75, respectively. Concentrations remained significantly higher patients even after controlling AMH levels. IGF-2 IGFBP-1 groups. CONCLUSIONS Measurement circulating initiation has potential have increased likelihood be cancelled.