Study of Pseudomonas aeruginosa Serotype O12 Isolates with a Common Antibiotic Susceptibility Pattern

摘要: A multicentre European study ofPseudomonas aeruginosa serotype O12 isolates with a common antibiotic resistance pattern was conducted. Resistance to β-lactams and aminoglycosides observed in 24 of the 25 isolates, as often reported Europe, all were significantly more susceptible fosfomycin than 189 other serotypes (72% vs. 13.2%). The mutational frequency similar that thus could not explain susceptibility fosfomycin. As number epidemiological studies using various methods, especially ribotyping withEcoRI, have shown most strains are similar, it has been suggested single strain this is widespread. However, withEcoRI andPvull distinguished seven clones among ticarcillin resistant although one ribotype predominated (67%). Thus hypothesis spread clone across Europe cannot phenotype different O12. beta-lactams might be explained by greater receptiveness for transposable mechanisms, increased permeability outer membrane.