Fulminant hepatic failure: etiology, viral markers and outcome.

摘要: OBJECTIVE To investigate the etiology and outcome of fulminant hepatic failure (FHF) in children. SETTING Hospital based descriptive. METHODS 36 children (22 males 14 females) presenting with FHF over a period one year were investigated. The ages ranged from 1.5 to 9 years. was defined as occurrence encephalopathy within eight weeks onset jaundice no evidence pre-existing liver disease. Detailed history, clinical examination, routine biochemical parameters relevant diagnostic tests carried out. Viral markers studied anti HAV-IgM, HBsAg, HBc-IgM, anti-HCV HEV-IgM. RESULTS A viral could be established 22 (61.1%). Hepatitis (n = 12), B 3), 2), E 4). Two had enteric fever (1 associated HEV), 2 Wilson's disease, 1 child Indian Childhood Cirrhosis (ICC) drug induced hepatitis. Etiological diagnosis not possible 8 (22%). Fourteen (39%) died. Poor spontaneous bleeding, raised prothrombin time, lower transaminases higher bilirubin on admission. CONCLUSION hepatitis is commonest cause HAV alone or combination responsible for upto 50% all Chronic disease can also present FHF. one-fourth cases.