Off-pathway α-synuclein oligomers seem to alter α-synuclein turnover in a cell model but lack seeding capability in vivo

Maria Grazia Spillantini, Marie Luise Schmidt, Virginia M.-Y. Lee, John Q. Trojanowski, Ross Jakes, Michel Goedert, α-Synuclein in Lewy bodies Nature. ,vol. 388, pp. 839- 840 ,(1997) , 10.1038/42166

Kelvin C Luk, Victoria Kehm, Jenna Carroll, Bin Zhang, Patrick O’Brien, John Q Trojanowski, Virginia M-Y Lee, Pathological α-Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice Science. ,vol. 338, pp. 949- 953 ,(2012) , 10.1126/SCIENCE.1227157

K. M. Danzer, D. Haasen, A. R. Karow, S. Moussaud, M. Habeck, A. Giese, H. Kretzschmar, B. Hengerer, M. Kostka, Different Species of α-Synuclein Oligomers Induce Calcium Influx and Seeding The Journal of Neuroscience. ,vol. 27, pp. 9220- 9232 ,(2007) , 10.1523/JNEUROSCI.2617-07.2007

Tomas Näsström, Therese Wahlberg, Mikael Karlsson, Fredrik Nikolajeff, Lars Lannfelt, Martin Ingelsson, Joakim Bergström, The lipid peroxidation metabolite 4-oxo-2-nonenal cross-links α-synuclein causing rapid formation of stable oligomers Biochemical and Biophysical Research Communications. ,vol. 378, pp. 872- 876 ,(2009) , 10.1016/J.BBRC.2008.12.005

Dong-Pyo Hong, Anthony L. Fink, Vladimir N. Uversky, Structural Characteristics of α-Synuclein Oligomers Stabilized by the Flavonoid Baicalein Journal of Molecular Biology. ,vol. 383, pp. 214- 223 ,(2008) , 10.1016/J.JMB.2008.08.039

Tiago Fleming Outeiro, Preeti Putcha, Julie E. Tetzlaff, Robert Spoelgen, Mirjam Koker, Filipe Carvalho, Bradley T. Hyman, Pamela J. McLean, Correction: Formation of Toxic Oligomeric α-Synuclein Species in Living Cells PLOS ONE. ,vol. 3, ,(2008) , 10.1371/ANNOTATION/9282F173-DF82-4B70-9120-B4E62B3DACB1

Therese Fagerqvist, Veronica Lindström, Eva Nordström, Anna Lord, Stina M. E. Tucker, Xingjian Su, Charlotte Sahlin, Alex Kasrayan, Jessica Andersson, Hedvig Welander, Thomas Näsström, Mats Holmquist, Heinrich Schell, Philipp J. Kahle, Hannu Kalimo, Christer Möller, Pär Gellerfors, Lars Lannfelt, Joakim Bergström, Martin Ingelsson, Monoclonal antibodies selective for α-synuclein oligomers/protofibrils recognize brain pathology in Lewy body disorders and α-synuclein transgenic mice with the disease-causing A30P mutation. Journal of Neurochemistry. ,vol. 126, pp. 131- 144 ,(2013) , 10.1111/JNC.12175

Thomas Näsström, Therese Fagerqvist, Mikael Barbu, Mikael Karlsson, Fredrik Nikolajeff, Alex Kasrayan, Monica Ekberg, Lars Lannfelt, Martin Ingelsson, Joakim Bergström, The lipid peroxidation products 4-oxo-2-nonenal and 4-hydroxy-2-nonenal promote the formation of α-synuclein oligomers with distinct biochemical, morphological, and functional properties Free Radical Biology and Medicine. ,vol. 50, pp. 428- 437 ,(2011) , 10.1016/J.FREERADBIOMED.2010.11.027

P. Desplats, H.-J. Lee, E.-J. Bae, C. Patrick, E. Rockenstein, L. Crews, B. Spencer, E. Masliah, S.-J. Lee, Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 106, pp. 13010- 13015 ,(2009) , 10.1073/PNAS.0903691106

Eun-Jin Bae, Dong-Hwan Ho, Eunbi Park, Jin Woo Jung, Kyungcho Cho, Ji Hye Hong, He-Jin Lee, Kwang Pyo Kim, Seung-Jae Lee, None, Lipid Peroxidation Product 4-Hydroxy-2-Nonenal Promotes Seeding-Capable Oligomer Formation and Cell-to-Cell Transfer of α-Synuclein Antioxidants & Redox Signaling. ,vol. 18, pp. 770- 783 ,(2013) , 10.1089/ARS.2011.4429