Bone metabolism in oxalosis: a single-center study using new imaging techniques and biomarkers

作者: Justine Bacchetta , Sonia Fargue , Stéphanie Boutroy , Odile Basmaison , Nicolas Vilayphiou

DOI: 10.1007/S00467-010-1453-X

关键词:

摘要: The deposition of calcium oxalate crystals in the kidney and bone is a hallmark primary hyperoxaluria type 1 (PH1). We report here an evaluation status 12 PH1 children based on biomarkers [parathyroid hormone, vitamin D, fibroblast growth factor 23 (FGF23)] radiological assessments (skeletal age, three-dimensional high-resolution peripheral quantitative computed tomography, HR-pQCT) carried out within framework cross-sectional single-center study. controls consisted healthy with chronic disease already enrolled local mineral metabolism studies. mean age (±standard deviation) patients was 99 (±63) months. Six suffered from fracture. Bone maturation accelerated five patients, four whom were <5 years. combination new imaging techniques highlighted unexplained features PH1: advanced skeletal young increased FGF23 levels decreased total volumetric density microarchitecture alteration.

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