Intravascular ultrasound assessment of lumen size and wall morphology in normal subjects and patients with coronary artery disease.

摘要: BACKGROUND Necropsy studies demonstrate that coronary artery disease (CAD) is frequently complex and eccentric. However, angiography provides only a silhouette of the vessel lumen. Intravascular ultrasound new tomographic imaging method for evaluation dimensions wall morphology. Few data exist regarding intravascular in patients with CAD, no subjects normal coronaries. METHODS AND RESULTS We used multielement 5.5F, 20-MHz catheter to examine eight 43 CAD. assessed safety effect eccentricity on comparison minimum luminal diameter by ultrasound. Normal atherosclerotic morphology stenosis severity were also evaluated The untoward was transient spasm five patients. At 33 sites subjects, lumen nearly circular, yielding close correlation between angiographic ultrasonic (r = 0.92). 90 demonstrated concentric cross section; 0.93). at 72 eccentric sites, not as 0.77). For 41 stenoses, area reduction moderate 0.63). In revealed thin (0.30 mm or less) intimal leading edge subadjacent sonolucent zone (0.20 less). Patients CAD exhibited increased thickness echogenicity edge, thickened zones, and/or attenuation transmission. CONCLUSIONS These establish feasible safe yields measurements correlate generally angiography. Differences measures size vessels probably reflect dissimilar perspectives techniques. detailed images abnormal previously possible vivo.