Vascular proliferation and atherosclerosis: New perspectives and therapeutic strategies

摘要: In atherosclerosis, the vascular smooth muscle cell (VSMC) contributes to vessel wall inflammation and lipoprotein retention, as well formation of fibrous cap that provides stability plaque. The VSMC can undergo a proliferative response underlies development in-stent restenosis, bypass graft occlusion transplant vasculopathy. Although benefit/risk therapeutic inhibition proliferation in atherosclerosis is unclear, experimental human evidence strongly suggests potential antiproliferative therapy for failure other disorders.