摘要: The perimenopause is a time of significant hormonal changes. hallmark these changes vasomotor symptoms such as night sweats and hot flashes. Other purported effects changing hormones include sexual dysfunction, sleep disruption, mood disturbances, host other symptoms. This chapter reviews the epidemiologic literature on in functioning with age, particularly focusing menopause. Some may increase age whereas others appear to be transitory. also describes functional impact neuroendocrine their interrelatedness. Several methodological issues are noteworthy order consider reviewing this area research. These usually distinction between clinic population-based samples, defining menopause status, measuring functioning, well limitations cross-sectional Much research based samples from patients who report problems, or women have sought treatment for related problems.