Circulating MiRNAs as biomarkers of gait speed responses to aerobic exercise training in obese older adults

作者: Tan Zhang , Tina E. Brinkley , Keqin Liu , Xin Feng , Anthony P. Marsh

DOI: 10.18632/AGING.101199

关键词:

摘要: Gait speed is a useful predictor of adverse outcomes, including incident mobility disability and mortality in older adults. While aerobic exercise training (AEX) generally an effective therapy to improve gait speed, individual responses are highly variable. Circulating microRNAs (miRNAs) may contribute inter-individual changes with AEX. We examined whether plasma miRNAs associated (dGaitSp) 33 obese adults (age: 69.3±3.6 years, BMI: 34.0±3.1 kg/m2, 85% white, 73% women) who performed treadmill walking, 4 days/week for 5 months. (baseline: 1.02±0.19 m/s; range response: -0.2 0.35 m/s) was assessed using 400 meter-fast-paced walk test. Using Nanostring technology, 120 out 800 were found be abundantly expressed these significantly changed after AEX: miR-376a-5p increased, while miR-16-5p, miR-27a-3p, miR-28-3p all decreased. In addition, baseline miR-181a-5p levels (r=-0.40, p=0.02) percent miR-92a-3p (r=-0.44, p=0.009) negatively dGaitSp. Linear regression combined showed even stronger associations dGaitSp (r=-0.48, p=0.005). These results suggest that circulating predict and/or regulate AEX-induced

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