Interaction between Y chromosome haplogroup O3* and 4-n-octylphenol exposure reduces the susceptibility to spermatogenic impairment in Han Chinese.

摘要: Certain genetic background (mainly Y chromosome haplogroups, Y-hg) may modify the susceptibility of certain environmental exposure to some diseases. Compared with respective main effects or exposure, interactions between them reflect more realistic combined on a disease. To identify spermatogenic impairment, we performed haplotyping and measurement 9 urinary phenols concentrations in 774 infertile males 520 healthy controls Han Chinese population, likelihood ratio tests were used examine Y-hgs phenols. Originally, observed that Y-hg C F* might male infertility 4-n-octylphenol (4-n-OP) level (Pinter = 0.005 0.019, respectively). Subsequently, based our results, two panels tested possible protective sub-branches 4-n-OP O3* was uncovered interact 0.019). In conclusion, while shows an adverse effect spermatogenesis, makes individuals adaptive such for maintaining basic reproductive capacity.