Decreased Streptococcus pneumoniae susceptibility to oral antibiotics among children in rural Vietnam: a community study

摘要: Streptococcus pneumoniae is the most significant bacterial cause of community-acquired pneumonia among children under five years worldwide. Updated resistance information S. essential to adjust recommendations for empirical treatment pneumonia, which will have immense implications local and global health. This study investigated prevalence antibiotic in isolated strains relationship with use demographic factors rural Vietnam 2007. In Bavi district, 847 6 60 months were selected from households. The main child-caregivers households interviewed weekly using structured questionnaires collect daily illness symptoms drug child over a four-week period (from March through June 2007). 3rd week, invited clinical examination nasopharyngeal samples identification. Etest disk diffusion used test susceptibility. Of 818 participating children, 258 (32%) had ongoing respiratory infections, 421 (52%) carried pneumoniae, 477 (58%) antibiotics within previous three weeks. isolates, 95% resistant at least one (401/421). Resistance co-trimoxazole, tetracycline, phenoxymethylpenicillin, erythromycin ciprofloxacin was 78%, 75%, 70% 28%, respectively. Low noted amoxicillin (4%), benzylpenicillin cefotaxime (2%). intermediate 32%. Multidrug-resistance seen 60%. common pattern co-resistance tetracycline erythromycin. proportion carrying bacteria higher who commonly multidrug-resistance area remarkably high. High-dose only oral that can possibly be pneumococcal infections. Strategies promote appropriate prescribing dispensing effective should immediately implemented benefit