How does the femoral cortex depend on bone shape? A methodology for the joint analysis of surface texture and shape.

摘要: In humans, there is clear evidence of an association between hip fracture risk and femoral neck bone mineral density, some the shape proximal femur. Here, we investigate whether cortex plays a role in these associations: do particular morphologies predispose to weaker cortices? To answer this question, used cortical mapping measure distribution mass surface density (CMSD, mg/cm2) cohort 125 females. Principal component analysis surfaces identified three modes variation accounting for 65% population variance. We then statistical parametric (SPM) locate regions where CMSD depends on shape, allowing age. Our principal findings were increased with gracility over much femur; decreased at superior neck, coupled calcar femorale, increasing neck-shaft angle. obtaining results, studied spatial normalization SPM, identifying systematic misregistration as major impediment joint shape. Through series experiments synthetic data, evaluated number registration methods normalization, concluding that only those predicated explicit set homologous landmarks are suitable kind analysis. The emergent methodology amounts extension Geometric Morphometric Image Analysis domain textured surfaces, alongside protocol labelling clinical CT scans human