Preparation and spectroscopic studies on charge-transfer complexes of famciclovir drug with different electron acceptors
作者： Akmal S. Gaballa , Said M. Teleb , El-Metwally Nour
DOI: 10.1016/J.MOLSTRUC.2012.04.092
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摘要: Abstract The CT-interaction of electron acceptors such as chloranilic acid (H 2 CA), 2,3-dichloro-5,6-dicyano- p -benzoquinone (DDQ) and 7,7′,8,8′-tetracyano-p-quinodimethane (TCNQ) with the antiviral drug famciclovir (FCV) have been investigated spectrophotometrically in defined solvent. data indicate formation CT-complexes general formula [(FCV)(acceptor)]. 1:1 stoichiometry (FCV)-acceptors were based on elemental analysis, IR spectra thermogravimetric analysis solid along photometric titration measurements for reactions. constants ( K CT ) are shown to be strongly dependent type structure acceptor. Factors affecting CT-processes redox potentials steric hinderance reactants discussed.
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