Stimulation of Insulin Secretion by Theophylline
作者： JOHN R. TURTLE , GEORGE K. LITTLETON , DAVID M. KIPNIS
DOI: 10.1038/213727A0
关键词:
摘要: RECENT reports that epinephrine and glucagon, hormones which affect the generation of cyclic 3′,5′-AMP, also influence release pancreatic insulin1–5 have led us to examine effect this nucleotide on insulin secretion. In present experiments effects secretion theophylline, a methyl xanthine derivative inhibits phosphodiesterase6 increases intracellular steady state level alone in combination with alpha beta adrenergic blocking agents, been examined rat.
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Martin A. Rizack, ACTIVATION OF AN EPINEPHRINE-SENSITIVE LIPOLYTIC ACTIVITY FROM ADIPOSE TISSUE BY ADENOSINE 3',5'-PHOSPHATE. Journal of Biological Chemistry. ,vol. 239, pp. 392- 395 ,(1964) , 10.1016/S0021-9258(18)51690-2
T. W. Rall, Earl W. Sutherland, THE RELATION OF ADENOSINE-3', 5'-PHOSPHATE AND PHOSPHORYLASE TO THE ACTIONS OF CATECHOLAMINES AND OTHER HORMONES Pharmacological Reviews. ,vol. 12, pp. 265- 299 ,(1960)
R.W. Butcher, R.J. Ho, H.C. Meng, Earl W. Sutherland, Adenosine 3',5'-monophosphate in biological materials. II. The measurement of adenosine 3',5'-monophosphate in tissues and the role of the cyclic nucleotide in the lipolytic response of fat to epinephrine. Journal of Biological Chemistry. ,vol. 240, pp. 4515- 4523 ,(1965) , 10.1016/S0021-9258(18)97092-4
J.S. Handler, R.W. Butcher, Earl W. Sutherland, J. Orloff, The effect of vasopressin and of theophylline on the concentration of adenosine 3',5'-phosphate in the urinary bladder of the toad. Journal of Biological Chemistry. ,vol. 240, pp. 4524- 4526 ,(1965) , 10.1016/S0021-9258(18)97093-6
F. Murad, Y.-M. Chi, T.W. Rall, Earl W. Sutherland, Adenyl cyclase. III. The effect of catecholamines and choline esters on the formation of adenosine 3',5'-phosphate by preparations from cardiac muscle and liver. Journal of Biological Chemistry. ,vol. 237, pp. 1233- 1238 ,(1962) , 10.1016/S0021-9258(18)60314-X
Michael Somogyi, NOTES ON SUGAR DETERMINATION Journal of Biological Chemistry. ,vol. 195, pp. 19- 23 ,(1926) , 10.1016/S0021-9258(18)84465-9
R.W. Butcher, Earl W. Sutherland, Adenosine 3',5'-phosphate in biological materials. I. Purification and properties of cyclic 3',5'-nucleotide phosphodiesterase and use of this enzyme to characterize adenosine 3',5'-phosphate in human urine. Journal of Biological Chemistry. ,vol. 237, pp. 1244- 1250 ,(1962) , 10.1016/S0021-9258(18)60316-3
M. Rosell-Perez, J. Larner, Studies on UDPG-α-glucan Transglucosylase. V. Two Forms of the Enzyme in Dog Skeletal Muscle and Their Interconversion* Biochemistry. ,vol. 3, pp. 81- 88 ,(1964) , 10.1021/BI00889A014
W. M. HUNTER, F. C. GREENWOOD, Preparation of Iodine-131 Labelled Human Growth Hormone of High Specific Activity Nature. ,vol. 194, pp. 495- 496 ,(1962) , 10.1038/194495A0
Ellis Samols, Germano Marri, Vincent Marks, PROMOTION OF INSULIN SECRETION BY GLUCAGON. The Lancet. ,vol. 286, pp. 415- 416 ,(1965) , 10.1016/S0140-6736(65)90761-0