Effects of chronic stress on sleep in rats

摘要: The present study was conducted to determine the effects of chronic stress on sleep using a rodent paradigm around-the-clock signalled intermittent foot shock in which some rats can pull chain avoid/escape while another group is yoked first group. We measured telemetry; four-channel EEG collected 24 h/day during 2 prestress days; days 1, 2, 3, 7, and 14 stress; 3 poststress days. States REM sleep, non-REM (NREM) waking were scored for each 15-s period recordings. During period, slept (REM plus NREM) 55% available time light hours 34% dark with remainder represented by waking. On day stress, total and, especially decreased markedly. By second only controllable (but not uncontrollable group) still significantly compared levels, returned baseline levels 7 stress. recovery quantity accomplished increased hours, resulting long-lasting disruption normal circadian patterning.