Bergenin decreases the morphine-induced physical dependence via antioxidative activity in mice

摘要: Oxidative stress plays a role in the development of physical dependence induced by morphine. Bergenin, polyphenol found many Asian, African, and South American medicinal plants, is potent antinarcotic agent with wide spectrum pharmacological activities including antioxidant action. In present study, we observed that bergenin decreased morphine mice activity effects through adapting to morphine-induced oxidative brain. The naloxone-precipitated withdrawal symptom (jumping frequency) was significantly ameliorated (50% control group) administration (20 mg/kg) morphine-treated mice. Furthermore, down-regulation glutathione (GSH) contents reversed frontal cortex liver. Bergenin had no on increased levels nfr2-dependent enzyme HO1 NQO1 cortex, striatum, liver However, increase nrf2 nuclear translocation striatum inhibited treatment. These results suggest has potential effect via regulation GSH stress.