摘要: The description of limb girdle dystrophy by Wilhelm Erb [1] and pseudohypertrophic Duchenne [2] initiated a chapter in disorders affecting striated muscle, which within the last fifteen years has rapidly accelerated, so that now over forty different neuromuscular system are recognized. Of these, twelve have been described decade. these twelve, seven since 1962. utilization chemical, electrophysiological, cyto-chemical ultrastructural anatomic techniques added new dimensions to studies muscle cell. My assignment today is discuss with you role intracellular organelles disease muscle. To be able do at University Heidelberg, must ranked as one birthplaces neurology, on 125th anniversary birth signal honor my university me. Pennsylvania School Medicine oldest United States, year celebrating its two-hundredth anniversary. It was this William Spiller did his work [3, 4]. perhaps appropriate first department neurology America also founded almost hundred ago 1871 Pennsylvania. Let us see changes occurred our knowledge cell combined two fifty institutions Erb.