An Electrophysiological Study of Ganglion Blockade by Paraquat and Diquat
作者： D.B. Webb , E.J. Ansari , D.I. Wallis
DOI: 10.1177/096032718800700609
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摘要: 1. The bipyridilium herbicides, particularly paraquat, have chemical and toxicological features in common with the bi-quaternary ammonium ganglion blockers. 2. Paraquat diquat were tested for blocking activity. Rabbit cervical ganglia superfused both agents subsequently hexamethonium to confirm susceptibility blockade. 3. No evidence blockade was found at either supra maximal or sub stimulation, none following repetitive stimulation. 4. similarities differences between bipyridyl herbicides blockers can be explained on basis of their structures. 5. It is concluded that neither paraquat nor significant
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