Adhesion GPCRs in Kidney Development and Disease.

摘要: Chronic kidney disease (CKD) represents the fastest growing pathology worldwide with a prevalence of >10% in many countries. In addition, cancer 5% all new diagnosed cancers. As currently no effective therapies exist to restore function after CKD- as well cancer-induced renal damage, it is important elucidate regulators development and therapeutic targets. G protein-coupled receptors (GPCRs) represent most successful class pharmaceutical recent years adhesion GPCRs (aGPCRs), second largest GPCR family, gained significant attention they are present on almost mammalian cells, associated plethora diseases regulate cellular processes. aGPCRs for example cell polarity, mitotic spindle orientation, migration, aggregation; processes that play roles and/or disease. Moreover, polycystin-1, major regulator disease, contains GAIN domain, which otherwise only found aGPCRs. this review, we assess potential targets For purpose have summarized available literature analyzed data from databases The Human Protein Atlas, EURExpress, Nephroseq, FireBrowse, cBioPortal Cancer Genomics National Institute Genomic Data Commons portal (NCIGDC). Our indicate expressed different spatio-temporal patterns during altered aGPCR expression variety including CKD, diabetic nephropathy, lupus nephritis carcinoma. We conclude promising might be useful diagnostic markers