Aptamer mediated niosomal drug delivery

摘要: Development of nanoscale carrier systems for targeted drug delivery is crucial cancer treatment. The current methods exhibit some problems such as lack therapy efficiency at the desired parts body, degradation before reaching tissue and limitations in cellular penetration. In this work, a novel platform was developed to overcome these enable specific efficient uptake into cells. surface synthesized polyethylene glycolated niosomes (PEGNIO) modified with cell penetrating peptide (CPP) MUC1 (S2.2) aptamer, doxorubicin (DOX) model encapsulated platform. Fluorescence microscopy flow cytometry analysis were used investigate intracellular distribution DOX loaded niosomal formulation. vitro cytotoxicity studies carried out using positive HeLa negative U87 Moreover, dynamic light scattering (DLS), zeta potential measurements fluorescence absorption spectroscopy performed determine vesicle size, well charge spectroscopic properties conjugates. From results, aptamer mediated may have application towards MUC1-overexpressing tumors.