Growth Hormone and Osteoporosis

摘要: Since the first demonstration of activity human and monkey pituitary growth hormone (GH) extracts in humans (1,2), research regarding effect GH on bone have focused primarily hormone’s promotion linear growth. In last decade, however, importance role metabolism has become increasingly apparent. Recent demonstrated that administration stimulates osteoblast proliferation promotes formation vitro vivo, deficient states are associated with osteoporosis. addition, normal aging been shown to be both declining secretion density, suggesting a possible link between senile A number technical advances aided this work. studies advanced by new cell-culture techniques recombinant DNA technology. Studies assessed turnover widening array serum urine markers. These include markers, byproducts formation, markers resorption. Furthermore, refinements measurement mineral content density permitted long term mass. This chapter will address relationship osteoporosis reviewing cells, patients deficiency, using different model systems.