cGAS in action: Expanding roles in immunity and inflammation
作者： Andrea Ablasser , Zhijian J. Chen
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摘要: … are formed, which are prone to rupture unpredictably and cause cGAS activation (66, 67). After periods of progressive stress, senescent cells remodel their nuclear envelope, and this is …
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Yanick J. Crow, Nicolas Manel, Aicardi–Goutières syndrome and the type I interferonopathies Nature Reviews Immunology. ,vol. 15, pp. 429- 440 ,(2015) , 10.1038/NRI3850
Andrea Ablasser, Marion Goldeck, Taner Cavlar, Tobias Deimling, Gregor Witte, Ingo Röhl, Karl-Peter Hopfner, Janos Ludwig, Veit Hornung, cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING Nature. ,vol. 498, pp. 380- 384 ,(2013) , 10.1038/NATURE12306
Nicole Dobbs, Nikolay Burnaevskiy, Didi Chen, Vijay K. Gonugunta, Neal M. Alto, Nan Yan, STING Activation by Translocation from the ER Is Associated with Infection and Autoinflammatory Disease Cell Host & Microbe. ,vol. 18, pp. 157- 168 ,(2015) , 10.1016/J.CHOM.2015.07.001
Elizabeth E. Gray, Piper M. Treuting, Joshua J. Woodward, Daniel B. Stetson, Cutting Edge: cGAS Is Required for Lethal Autoimmune Disease in the Trex1-Deficient Mouse Model of Aicardi–Goutières Syndrome Journal of Immunology. ,vol. 195, pp. 1939- 1943 ,(2015) , 10.4049/JIMMUNOL.1500969
Leticia Corrales, Laura Hix Glickman, Sarah M. McWhirter, David B. Kanne, Kelsey E. Sivick, George E. Katibah, Seng-Ryong Woo, Edward Lemmens, Tamara Banda, Justin J. Leong, Ken Metchette, Thomas W. Dubensky, Thomas F. Gajewski, Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity Cell Reports. ,vol. 11, pp. 1018- 1030 ,(2015) , 10.1016/J.CELREP.2015.04.031
Matteo Gentili, Joanna Kowal, Mercedes Tkach, Takeshi Satoh, Xavier Lahaye, Cécile Conrad, Marilyn Boyron, Bérangère Lombard, Sylvère Durand, Guido Kroemer, Damarys Loew, Marc Dalod, Clotilde Théry, Nicolas Manel, Transmission of innate immune signaling by packaging of cGAMP in viral particles. Science. ,vol. 349, pp. 1232- 1236 ,(2015) , 10.1126/SCIENCE.AAB3628
Nadia Jeremiah, Bénédicte Neven, Matteo Gentili, Isabelle Callebaut, Sophia Maschalidi, Marie-Claude Stolzenberg, Nicolas Goudin, Marie-Louis Frémond, Patrick Nitschke, Thierry J Molina, Stéphane Blanche, Capucine Picard, Gillian I Rice, Yanick J Crow, Nicolas Manel, Alain Fischer, Brigitte Bader-Meunier, Frédéric Rieux-Laucat, None, Inherited STING-activating mutation underlies a familial inflammatory syndrome with lupus-like manifestations Journal of Clinical Investigation. ,vol. 124, pp. 5516- 5520 ,(2014) , 10.1172/JCI79100
Hiroki Ishikawa, Zhe Ma, Glen N. Barber, STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity Nature. ,vol. 461, pp. 788- 792 ,(2009) , 10.1038/NATURE08476
Thomas Marichal, Keiichi Ohata, Denis Bedoret, Claire Mesnil, Catherine Sabatel, Kouji Kobiyama, Pierre Lekeux, Cevayir Coban, Shizuo Akira, Ken J Ishii, Fabrice Bureau, Christophe J Desmet, DNA released from dying host cells mediates aluminum adjuvant activity Nature Medicine. ,vol. 17, pp. 996- 1002 ,(2011) , 10.1038/NM.2403
Yun-Gui Yang, Tomas Lindahl, Deborah E. Barnes, Trex1 Exonuclease Degrades ssDNA to Prevent Chronic Checkpoint Activation and Autoimmune Disease Cell. ,vol. 131, pp. 873- 886 ,(2007) , 10.1016/J.CELL.2007.10.017