Assessment by Extended-Coverage Next-Generation Sequencing Typing of DPA1 and DPB1 Mismatches in Siblings Matching at HLA-A, -B, -C, -DRB1, and -DQ Loci.
作者： Livia Mariano , Bing Melody Zhang , Kazutoyo Osoegawa , Robert Lowsky , Marcelo Fernandez-Vina
DOI: 10.1016/J.BBMT.2019.07.033
关键词:
摘要: ABSTRACT Allogeneic hematopoietic stem cell transplant from an HLA matched sibling donor is usually the preferable choice. The use of next-generation sequencing (NGS) for typing in clinical practice provides broader coverage and higher resolution genes. We evaluated frequency DPB1 crossing-over events among patients potential related donors typed with NGS. From July 2016 to January 2018, 593 2385 siblings were typed. matching status 546 patients, 44.8% these had that at HLA-A, -B, -C, -DRB1, -DQB1 loci. In 306 patient–HLA pairs, we found 6 pairs (1.96%) 1 mismatch, 5 included additional mismatch DPA1. No mismatches observed low expression Using T epitope algorithm, 4 DP classified as permissive, nonpermissive host-versus-graft direction, graft-versus-host direction. DPA1 low, their impact transplants not well established. Although goes beyond guidelines, it especially relevant sensitized patients. NGS-based full gene coverage, its can enable better selection.
tctjournal.org参考文章(13)
Stefan O. Ciurea, Rima M. Saliba, Gabriela Rondon, Poliana A. Patah, Fleur Aung, Pedro Cano, Borje S. Andersson, Partow Kebriaei, Uday Popat, Marcelo Fernandez-Vina, Richard E. Champlin, Marcos de Lima, Outcomes of Patients with Myeloid Malignancies Treated with Allogeneic Hematopoietic Stem Cell Transplantation from Matched Unrelated Donors Compared with One Human Leukocyte Antigen Mismatched Related Donors Using HLA Typing at 10 Loci Biology of Blood and Marrow Transplantation. ,vol. 17, pp. 923- 929 ,(2011) , 10.1016/J.BBMT.2010.10.017
Katharina Fleischhauer, Bronwen E Shaw, Theodore Gooley, Mari Malkki, Peter Bardy, Jean-Denis Bignon, Valérie Dubois, Mary M Horowitz, J Alejandro Madrigal, Yasuo Morishima, Machteld Oudshoorn, Olle Ringden, Stephen Spellman, Andrea Velardi, Elisabetta Zino, Effie W Petersdorf, None, Effect of T-cell-epitope matching at HLA-DPB1 in recipients of unrelated-donor haemopoietic-cell transplantation: a retrospective study Lancet Oncology. ,vol. 13, pp. 366- 374 ,(2012) , 10.1016/S1470-2045(12)70004-9
Bianca Schöne, Sabine Bergmann, Kathrin Lang, Ines Wagner, Alexander H. Schmidt, Effie W. Petersdorf, Vinzenz Lange, Predicting an HLA-DPB1 expression marker based on standard DPB1 genotyping: Linkage analysis of over 32,000 samples. Human Immunology. ,vol. 79, pp. 20- 27 ,(2018) , 10.1016/J.HUMIMM.2017.11.001
T. Goeury, L. E. Creary, L. Brunet, M. Galan, M. Pasquier, B. Kervaire, A. Langaney, J.-M. Tiercy, M. A. Fernández-Viña, J. M. Nunes, A. Sanchez-Mazas, Deciphering the fine nucleotide diversity of full HLA class I and class II genes in a well-documented population from sub-Saharan Africa. HLA. ,vol. 91, pp. 36- 51 ,(2018) , 10.1111/TAN.13180
Neema P. Mayor, James D. Hayhurst, Thomas R. Turner, Richard M. Szydlo, Bronwen E. Shaw, Will P. Bultitude, Jex-Ray Sayno, Franco Tavarozzi, Katy Latham, Chloe Anthias, James Robinson, Henny Braund, Robert Danby, Julia Perry, Marie C. Wilson, Adrian J. Bloor, I. Grant McQuaker, Stephen MacKinnon, David I. Marks, Antonio Pagliuca, Michael N. Potter, Victoria T. Potter, Nigel H. Russell, Kirsty J. Thomson, J. Alejandro Madrigal, Steven G.E. Marsh, Recipients Receiving Better HLA-Matched Hematopoietic Cell Transplantation Grafts, Uncovered by a Novel HLA Typing Method, Have Superior Survival: A Retrospective Study Biology of Blood and Marrow Transplantation. ,vol. 25, pp. 443- 450 ,(2019) , 10.1016/J.BBMT.2018.12.768
Kazutoyo Osoegawa, Kalyan C. Mallempati, Sridevi Gangavarapu, Arisa Oki, Ketevan Gendzekhadze, Susana R. Marino, Nicholas K. Brown, Maria P. Bettinotti, Eric T. Weimer, Gonzalo Montero-Martín, Lisa E. Creary, Tamara A. Vayntrub, Chia-Jung Chang, Medhat Askar, Steven J. Mack, Marcelo A. Fernández-Viña, HLA alleles and haplotypes observed in 263 US families. Human Immunology. ,vol. 80, pp. 644- 660 ,(2019) , 10.1016/J.HUMIMM.2019.05.018
Michael Cullen, Stephen P. Perfetto, William Klitz, George Nelson, Mary Carrington, High-resolution patterns of meiotic recombination across the human major histocompatibility complex. American Journal of Human Genetics. ,vol. 71, pp. 759- 776 ,(2002) , 10.1086/342973
Laura Zito, Federico Sizzano, Elisabetta Zino, Martin Maiers, Arend Mulder, Cristina Toffalori, Luigi Naldini, Fabio Ciceri, Luca Vago, Katharina Fleischhauer, Pietro Crivello, The Impact of Amino Acid Variability on Alloreactivity Defines a Functional Distance Predictive of Permissive HLA-DPB1 Mismatches in Hematopoietic Stem Cell Transplantation Biology of Blood and Marrow Transplantation. ,vol. 21, pp. 233- 241 ,(2015) , 10.1016/J.BBMT.2014.10.017
C. Alan Howard, Marcelo A. Fernandez-Vina, Frederick R. Appelbaum, Dennis L. Confer, Steven M. Devine, Mary M. Horowitz, Adam Mendizabal, Ginna G. Laport, Marcelo C. Pasquini, Stephen R. Spellman, Recommendations for Donor Human Leukocyte Antigen Assessment and Matching for Allogeneic Stem Cell Transplantation: Consensus Opinion of the Blood and Marrow Transplant Clinical Trials Network (BMT CTN) Biology of Blood and Marrow Transplantation. ,vol. 21, pp. 4- 7 ,(2015) , 10.1016/J.BBMT.2014.09.017
T Büchler, D Gallardo, M Rodrı́guez-Luaces, J.M Pujal, A Grañena, Frequency of HLA-DPB1 disparities detected by reference strand-mediated conformation analysis in HLA-A, -B, and -DRB1 matched siblings. Human Immunology. ,vol. 63, pp. 139- 142 ,(2002) , 10.1016/S0198-8859(01)00376-7