A severe combined immunodeficiency mutation in the mouse

摘要: The most debilitating human lymphoid deficiency disease, known as severe combined immunodeficiency (SCID), impairs the differentiation of both T and B lymphocytes. Affected infants are highly susceptible to recurring infections viruses, fungi bacteria invariably die within 2 yr birth. Inheritance this congenital syndrome may show X-linked or autosomal recessive control. To date inheritance SCID has been observed in Arabian foals which represent only animal model disease but here we report an mutation mice that severely lymphopoiesis. Mice homozygous for have few if any lymphocytes; consequently they hypogammaglobulinaemic deficient immune functions mediated by These mice, therefore, a new investigating how be impaired state regulated normal state.