Altered surfactant protein B levels in transgenic mice do not affect clearance of bacteria from the lungs.
作者： Henry T Akinbi , Hetal Bhatt , William M Hull , Timothy E Weaver
DOI: 10.1203/00006450-199911000-00007
关键词:
摘要: To determine the role of surfactant protein B (SP-B) in bacterial clearance from airways, three groups mice expressing different levels SP-B were studied: wild-type mice, hemizygous and overexpressing transgenic mice. increased 5-fold relative to 2- 3-fold over littermates. Mice each group infected intratracheally with common airway pathogens, streptococci or Pseudomonas aeruginosa. There was no significant difference number recoverable viable bacteria at 6 h (group P. aeruginosa) 24 (P. among groups. Similarly, systemic dissemination not for both pathogens time points. We conclude that vivo do influence lungs.
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