Exhaled ethane is elevated in cystic fibrosis and correlates with carbon monoxide levels and airway obstruction.

摘要: Ethane is produced from lipid peroxidation and can be measured in the exhaled air. Cystic fibrosis (CF) characterized by recurrent respiratory infections, release of reactive oxygen species inflammatory cells, increased oxidative stress. We ethane 23 CF subjects (mean age ± SEM, 21 4 yr; 10 male, FEV1 62 4%) compared it with two other noninvasive markers stress inflammation, carbon monoxide (CO) nitric oxide (NO). Exhaled was collected during a flow pressure-controlled exhalation into reservoir discarding dead space air contaminated ambient A sample (2 ml) expired analyzed chromatography. levels were elevated patients not on steroids (n = 13, 1.99 0.20 ppb) steroid-treated 10, 0.67 0.09 ppb, p < 0.01) 14 nonsmoking control (8 men, 33 2.8 yr) (0.82 0.40 0.05). In steroid treatment correlated to airway obst...