Uncoupling activity of long-chian fatty acids
作者： P. Borst , J.A. Loos , E.J. Christ , E.C. Slater
DOI: 10.1016/0006-3002(62)90232-9
关键词:
摘要: 1. 1. At all pH values between 6.0 and 9.5 unsaturated long-chain fatty acids are more effective than the saturated in stimulating latent ATPase activity of fresh rat-liver mitochondria, provided Mg2+ is added. Oleic, linoleic, linolenic, arachidonic elaidic about equally effective. 2. 2. Whereas scarcely stimulate above 8 maximally active at PH 9. 3. 3. was required for maximal stimulation by oleic acid. In absence added acid completely inhibited stimulated 2,4-dinitro-phenol. 4. 4. Oleic concentration that gave complete loss ADP respiratory control or phosphate lowered P:O ratio with glutamate as substrate below I. With palmitic only partial. 5. 5. Uncoupling could be reserved adding serum albumin.
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