Does the interval from imaging to operation affect the rate of unanticipated metastasis encountered during operation for pancreatic adenocarcinoma?

摘要: Background Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with a propensity for early metastasis that often encountered unexpectedly at operation. Our objective was to examine the effect of time interval between preoperative imaging and attempted resection venue in which performed on frequency unanticipated (UM) We hypothesize obtained locally our hospital within 4 weeks operation will result lesser UM Methods Between January 2004 December 2009, records patients undergoing planned pancreatic PDAC high volume surgery center were compiled. Exclusion criteria included neoadjuvant therapy, prior resection, or evidence imaging. Review analysis clinical, radiographic, operative, pathologic data undertaken. Frequency outcome compared most recent cross-sectional (dual-phase contrast-enhanced CT MRI) defined as imaging-to-operation (IOI). Results Four-hundred eighty-seven met eligibility requirements study: 431 (88%) proximal 56 (12%) distal PDAC. 202 (41%) had their outside institution, no difference rates observed whether conducted institution (P > .05). Of 329 complete information analysis, discovered 60 (18%): 52 (18%) 293 8 (22%) 36 In PDAC, there linear relationship function weekly IOI (R2 = .99; P .006). For significant observed. Conclusion proximally located increases greater interval. Performing volume, elsewhere not associated decrease rate UM. Obtaining timely diagnostic may improve accuracy staging, thereby reduce number operations producing oncologic benefit.