What are the mechanisms for analogue and digital signalling in the brain?

摘要: Synaptic transmission in the brain generally depends on action potentials. However, recent studies indicate that subthreshold variation presynaptic membrane potential also determines spike-evoked transmission. The informational content of each is therefore greater than initially expected. contribution this synaptic property, which a fast (from 0.01 to 10 s) and state-dependent modulation functional coupling, has been largely underestimated could have important consequences for our understanding information processing neural networks. We discuss here how voltage terminal might modulate neurotransmitter release by mechanisms do not involve change Ca(2+) influx.