Longitudinal follow-up in 145 patients with medically refractory temporal lobe epilepsy treated surgically between 1984 and 1995.

摘要: Summary: Purpose: There are few studies of prolonged longitudinal follow-up after temporal resections. Methods: We analyzed 145 consecutive patients with lobe epilepsy treated surgically. Patients had a comprehensive presurgical evaluation, including video-EEG, psychometric testing, magnetic resonance imaging (MRI), singlephoton emission computed tomography (SPECT), intracarotid amobarbital procedure (IAP), and recently, volumetric head MRIs F-fluorodeoxyglucose-positron (FDG-PET) scans. Most en bloc resections, lesionectomies resection the epileptogenic zone. was no surgical mortality. Longitudinal data seizure outcome were by actuarial analysis. followed up at 6 weeks, 3 months, then on yearly basis. The mean 5.6 years. Results: Sixty-six percent free 1 year, 63% 2 years, 60% 5 55% 10 years follow-up. Moreover, 85%, became for 22 time last or rare seizures. who surgery, an 83% 92% probability, respectively, remaining Ninety-one small tumors cavernous angiomas compared 69% hippocampal sclerosis. Conclusions: Actuarial analysis showed that long-term remains favorable. Follow-up is highly predictive outcome. discrete lesions best late recurrences sclerosis gliosis. Some postoperative seizures eventually free, reflecting running-down phenomenon. Key Words: Temporal epilepsy-Long-term medically refractory comprise largest group undergoing surgery (1,2). This significant increase in number reflects fact as many 20-30% to medical treatment (3). these have abnormal mesial structures (MRI) focal functional deficits fluorodeoxyglucose positron Wada benefit from dysfunctional zone (43. With exceptions, most