Novel approaches to the treatment of the rodent malaria parasite Plasmodium berghei in vivo

摘要: The rapid increase in malarial drug resistance and the severe side effects related to high doses of current drugs have contributed urgent need for a new strategy treat malaria. In situ gel implantation is used solubility drugs, leading higher absorption body. addition, entrapping antimalarial nanocapsules has potential restore use older with toxic by modifying their bio-distribution, reducing toxicity, increasing efficacy. techniques tested free drug, systems, nanocarrier formulations against malaria parasites. A formulation 30% polymer solvent was as an gel, holding one three tested. Our experiments demonstrate that single dose preparation leads similar release multiple drug. However, 73%, 27%, 100% cure rate achieved silver sulphadiazine, halofantrine, chloroquine phosphate respectively. contrast, 0%, 66.7% same alone, late treatment did not result observed immediate treatment. In system, water-soluble prepared via double emulsion evaporation, while nonwater-soluble halofantrine sulphadiazine were interfacial deposition. vitro studies showed slower buffer saline media, when administered than formulation. both infections. Nanocarriers are more efficacious gelling systems This phenomenon attributable slow well size, charge, cellular uptake properties.