Theories of biological etiology of affective disorders.

摘要: Publisher Summary The existence of effective physical and pharmacological treatments mania depression provides an important avenue for investigation into the etiologies these disorders. It is germane to consider modes discovery antimanic antidepressant drugs, as well their etiological implications. body data on electrolyte steroid alterations in affective disorders then discussed, focusing findings etiological, rather than descriptive, significance. This chapter discusses evidence relating catecholamine hypothesis, briefly reviews work steroids metabolism. therapeutic effects monoamine oxidase (MAO) inhibitors treatment antihypertensive antipsychotic reserpine stimulated by basic scientists elucidating action drugs. most likely mechanism MAO was inhibition enzyme oxidase, which breaks down biogenic amines, such norepinephrine serotonin. Reserpine interferes with storage amines intracellular vesicles. Hence, raise brain levels many species (by inhibiting degradation) while depletes amines. fact that drugs either produce or relieve alter opposite ways suggested perhaps both may be caused amine