An fMRI study indicating increased cortical recruitment during a cognitive interference task in Huntington's disease patients

摘要: We used an event related fMRI design to study the BOLD response in Huntington’s disease (HD) patients during performance of a Simon interference task. hypothesised that HD will demonstrate significantly slower RTs than controls, and there be significant differences pattern brain activation between groups. Seventeen 15 age sex matched controls were scanned using 3T GE scanner (FOV = 24 cm2; TE 40 ms; TR 3 s; FA 60°; slice thickness 6 mm; in-plane resolution 1.88x1.88 mm2). The task involved two conditions, namely congruent (for example, left pointing arrow appearing on side screen) incongruent right screen), baseline condition. Each stimulus was presented for 2500 ms followed by blank screen 500 ms. Subjects instructed press button same hand as indicated direction head given 3000 respond. Data analysis performed SPM2 with random effects model. For each subject parameter estimates combined conditions (congruent combined) calculated. Comparisons such these, based block designs, have superior statistical power detecting subtle changes anywhere brain. activations reported are at PFDR_corr <0.05. anterior cingulate (AC), prefrontal, parietal, premotor* *regions activated patients, whereas only premotor, striatal regions. lack prefrontal involvement, striatum is possibly associated over simplified employed. This notion supported putamen region execution learned automatic behaviours. In conclusion showed hyperactivity fronto-striatal-parietal circuitry compared controls.