Antiinflammatory and Antiatherogenic Effects of the NF-κB Inhibitor Acetyl-11-Keto-β-Boswellic Acid in LPS-Challenged ApoE−/− Mice

摘要: Objective— In this article, we studied the effect of acetyl-11-keto-β-boswellic acid (AKβBA), a natural inhibitor proinflammatory transcription factor NF-κB on development atherosclerotic lesions in apolipoprotein E–deficient (apoE −/− ) mice. Methods and Results— Atherosclerotic were induced by weekly LPS injection apoE alone increased lesion size ≈100%, treatment with AKβBA significantly reduced it ≈50%. Moreover, activity was also plaques LPS-injected mice treated AKβBA. As consequence, led to significant downregulation several NF-κB–dependent genes such as MCP-1, MCP-3, IL-1α, MIP-2, VEGF, TF. By contrast, did not affect plasma concentrations triglycerides, total cholesterol, antioxidized LDL antibodies, various subsets lymphocyte-derived cytokines. potently inhibited IκB kinase (IKK) immunoprecipitated from LPS-stimulated mouse macrophages mononuclear cells leading decreased phosphorylation IκBα inhibition p65/NF-κB activation. Comparable AKβBA-mediated observed human macrophages. Conclusion— The plant resins species Boswellia family might represent an alternative for classical medicine treatments chronic inflammatory diseases atherosclerosis. (Arterioscler Thromb Vasc Biol. 2008;28:272-277)