A novel leptin receptor isoform in rat
作者： May-Yun Wang , Ting Zhou Yan , Christopher B Newgard , Roger H Unger , None
DOI: 10.1016/0014-5793(96)00790-9
关键词:
摘要: Five mouse and human leptin receptors (Ob-R) have recently been identified, a long isoform (Ob-Rb), preferentially expressed in hypothalamus, 4 short isoforms, Ob-Ra, Ob-Rc, Ob-Rd, Ob-Re. We identified new the rat, r-OB-Rf, with 6 C-terminal amino acids 3′ untranslated region without homology to other Ob-R isoforms. Its higher expression rat liver spleen compared brain, stomach, kidney, thymus, heart, lung contrasts Ob-Ra Ob-Rb homologues raises possibilities of as yet unidentified roles for members growing gene family.
elsevier.com
core.ac.uk 
sci-hub.se 参考文章(13)
D.P. Gearing, C.J. Thut, T. VandeBos, S.D. Gimpel, P.B. Delaney, J. King, V. Price, D. Cosman, M.P. Beckmann, Leukemia inhibitory factor receptor is structurally related to the IL-6 signal transducer, gp130. The EMBO Journal. ,vol. 10, pp. 2839- 2848 ,(1991) , 10.1002/J.1460-2075.1991.TB07833.X
Tetsuya Taga, Masahiko Hibi, Yuuichi Hirata, Katsuhiko Yamasaki, Kiyoshi Yasukawa, Tadashi Matsuda, Toshio Hirano, Tadamitsu Kishimoto, Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130 Cell. ,vol. 58, pp. 573- 581 ,(1989) , 10.1016/0092-8674(89)90438-8
Yiying Zhang, Ricardo Proenca, Margherita Maffei, Marisa Barone, Lori Leopold, Jeffrey M. Friedman, Positional cloning of the mouse obese gene and its human homologue Nature. ,vol. 372, pp. 425- 432 ,(1994) , 10.1038/372425A0
Tadamitsu Kishimoto, Tetsuya Taga, Shizuo Akira, Cytokine signal transduction Cell. ,vol. 76, pp. 253- 262 ,(1994) , 10.1016/0092-8674(94)90333-6
L. Campfield, F. Smith, Y Guisez, R Devos, P Burn, Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science. ,vol. 269, pp. 546- 549 ,(1995) , 10.1126/SCIENCE.7624778
Gwo-Hwa Lee, R. Proenca, J. M. Montez, K. M. Carroll, J. G. Darvishzadeh, J. I. Lee, J. M. Friedman, Abnormal splicing of the leptin receptor in diabetic mice Nature. ,vol. 379, pp. 632- 635 ,(1996) , 10.1038/379632A0
K. P. Hummel, M. M. Dickie, D. L. Coleman, Diabetes, a new mutation in the mouse Science. ,vol. 153, pp. 1127- 1128 ,(1966) , 10.1126/SCIENCE.153.3740.1127
Fredrik Lönnqvist, Peter Arner, Louise Nordfors, Martin Schalling, Overexpression of the obese ( ob ) gene in adipose tissue of human obese subjects Nature Medicine. ,vol. 1, pp. 950- 953 ,(1995) , 10.1038/NM0995-950
Louis A. Tartaglia, Marlene Dembski, Xun Weng, Nanhua Deng, Janice Culpepper, Rene Devos, Grayson J. Richards, L.Arthur Campfield, Frederick T. Clark, Jim Deeds, Craig Muir, Sean Sanker, Ann Moriarty, Karen J. Moore, John S. Smutko, Gail G. Mays, Elizabeth A. Wool, Cheryl A. Monroe, Robert I. Tepper, Identification and expression cloning of a leptin receptor Ob-R Cell. ,vol. 83, pp. 1263- 1271 ,(1995) , 10.1016/0092-8674(95)90151-5
Hong Chen, Olga Charlat, Louis A Tartaglia, Elizabeth A Woolf, Xun Weng, Stephen J Ellis, Nathan D Lakey, Janice Culpepper, Karen J More, Roger E Breitbart, Geoffrey M Duyk, Robert I Tepper, Jay P Morgenstern, Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell. ,vol. 84, pp. 491- 495 ,(1996) , 10.1016/S0092-8674(00)81294-5