Obesity and cancer: mechanistic insights from transdisciplinary studies

摘要: Obesity is associated with a range of health outcomes that are clinical and public significance, including cancer. Herein, we summarize epidemiologic preclinical evidence for an association between obesity increased risk breast prostate cancer incidence mortality. Moreover, describe data from observational studies weight change in humans calorie-restriction mouse models support potential role loss counteracting tumor-promoting properties cancers. Given challenging to achieve maintain, also consider linking treatments obesity-associated co-morbidities, metformin, statins non-steroidal anti-inflammatory drugs, reduced Finally, highlight several challenges should be considered when conducting research the area cancer, measurement population-based studies, timing relation tumor latency diagnosis, heterogeneous nature its co-morbidities. complex trait, comprised behavioral, molecular/metabolic factors, argue transdisciplinary approach key understanding mechanisms As such, this review highlights critical need integrate both gain insight into biologic non-biologic contributing obesity-cancer link.