Role of Pharmacokinetics in Chronotherapeutics

摘要: Life on Earth is dictated by circadian changes (e.g., sunlight, temperature, and humidity) in the environment caused planet’s rotation around its own axis. All forms of life have evolved clock system to adapt daily environmental changes. This adaptation results rhythms (a ~24-h oscillation) many physiological behavioral processes. The pharmacokinetics pharmacodynamics drugs are influenced fluctuations Chronopharmacokinetics, a subbranch chronopharmacology, studies variations pharmacokinetic processes (i.e., absorption, disposition, metabolism, excretion) drugs. Understanding contribution chronopharmacokinetics dosing time-dependent drug effects highly relevant for chronotherapeutics. In this chapter, we perform review influences both humans experimental animals. We also discuss role