The pathogenic and vaccine strains of equine infectious anemia virus differentially induce cytokine and chemokine expression and apoptosis in macrophages.
作者： Yue-Zhi Lin , Xue-Zhi Cao , Liang Li , Li Li , Cheng-Gang Jiang
DOI: 10.1016/J.VIRUSRES.2011.06.028
关键词:
摘要: The attenuated equine infectious anemia virus (EIAV) vaccine was the first lentivirus to be used in a large-scale application and has been successfully control spread of (EIA) China. To better understand potential role cytokines pathogenesis EIAV infection resulting immune response, we branched DNA technology compare mRNA expression levels 12 chemokines, including IL-1α, IL-1β, IL-4, IL-10, TNF-α, IFN-γ, IP-10, IL-8, MIP-1α, MIP-1β, MCP-1, MCP-2, monocyte-derived macrophages (eMDMs) infected with EIAV(DLV121) strain or parental EIAV(DLV34) pathogenic strain. Infection both caused changes various chemokines eMDMs. In early stage (0-24h), pro-inflammatory TNF-α IL-1β were significantly up-regulated, while EIAV(DLV121), anti-inflammatory cytokine IL-4 markedly up-regulated. effects on other similar between these two strains virus. During 4 days after infection, level cells higher than that strain, but IL-1α induced by observed addition, 5 not increased contrast, did up-regulate this level. Contrary our expectation, apoptosis eMDMs 6 infection. Together, results contribute greater understanding mechanisms which response is
elsevier.com
sci-hub.se 参考文章(45)
Veronica L. Scott, Crystal E. Boudreaux, Nikki N. Lockett, Brittany T. Clay, Karen S. Coats, Cytokine Dysregulation in Early- and Late-Term Placentas from Feline Immunodeficiency Virus (FIV)-Infected Cats American Journal of Reproductive Immunology. ,vol. 65, pp. 480- 491 ,(2011) , 10.1111/J.1600-0897.2010.00919.X
Osamu Yoshie, Toshio Imai, Hisayuki Nomiyama, Chemokines in immunity. Advances in Immunology. ,vol. 78, pp. 57- 110 ,(2001) , 10.1016/S0065-2776(01)78002-9
A Wanchu, P Suresh, Chemokines and chemokine receptors in HIV infection: role in pathogenesis and therapeutics. Journal of Postgraduate Medicine. ,vol. 52, pp. 210- 217 ,(2006)
Charles R. Mackay, Chemokines: immunology's high impact factors Nature Immunology. ,vol. 2, pp. 95- 101 ,(2001) , 10.1038/84298
Cheng-Gang Jiang, Xu Gao, Jian Ma, Yue-Zhi Lin, Xue-Feng Wang, Li-Ping Zhao, Yue-Ping Hua, Di Liu, Jian-Hua Zhou, None, C-terminal truncation of the transmembrane protein of an attenuated lentiviral vaccine alters its in vitro but not in vivo replication and weakens its potential pathogenicity. Virus Research. ,vol. 158, pp. 235- 245 ,(2011) , 10.1016/J.VIRUSRES.2011.04.007
Y. W. Lee, A. A. Hirani, N. Kyprianou, M. Toborek, Human immunodeficiency virus-1 Tat protein up-regulates interleukin-6 and interleukin-8 expression in human breast cancer cells. Inflammation Research. ,vol. 54, pp. 380- 389 ,(2005) , 10.1007/S00011-005-1371-8
Melissa A. Brown, John Hural, Functions of IL-4 and Control of Its Expression Critical Reviews in Immunology. ,vol. 37, pp. 181- 212 ,(2017) , 10.1615/CRITREVIMMUNOL.V37.I2-6.30
W.-S. Lim, S.L. Payne, J.F. Edwards, I. Kim, J.M. Ball, Differential effects of virulent and avirulent equine infectious anemia virus on macrophage cytokine expression Virology. ,vol. 332, pp. 295- 306 ,(2005) , 10.1016/J.VIROL.2004.11.027
Vilhjálmur Svansson, Mieke Roelse, Gudbjörg Ólafsdóttir, Lilja Thorsteinsdóttir, Einar G. Torfason, Sigurbjörg Torsteinsdóttir, Immune response against equine gammaherpesvirus in Icelandic horses. Veterinary Microbiology. ,vol. 137, pp. 363- 368 ,(2009) , 10.1016/J.VETMIC.2009.01.020
Venkatanarayanan Sharma, Ming Xu, Linda M. Ritter, Neil M. Wilkie, HIV-1tatInduces the Expression of a New Hematopoietic Cell-Specific Transcription Factor and Downregulates MIP-1α Gene Expression in Activated T-Cells Biochemical and Biophysical Research Communications. ,vol. 223, pp. 526- 533 ,(1996) , 10.1006/BBRC.1996.0928