PET imaging of cortical S2 serotonin receptors after stroke: lateralized changes and relationship to depression.

摘要: Patients with right-hemisphere strokes (N = 9) more than 1 year after injury had greater cortical binding of (3-N-[11C]methyl)spiperone a similar group patients left-hemisphere 8) or normal control subjects 17). The higher S2 serotonin receptor occurred in uninjured regions the right parietal and temporal cortex. ratio ipsilateral to contralateral cortex showed significant negative correlation severity depression scores left These findings suggest that biochemical response brain may be different depending on which hemisphere is injured some depressions consequence failure upregulate receptors stroke.