The joint association between F5 gene polymorphisms and maternal smoking during pregnancy on preterm delivery
作者： Yunxian Yu , Hui-Ju Tsai , Xin Liu , Karen Mestan , Shanchun Zhang
DOI: 10.1007/S00439-008-0589-2
关键词:
摘要: Factor V (F5) genetic variants and maternal smoking during pregnancy individually has been associated with increased risk of preterm delivery (PTD). We hypothesize that F5 gene may synergistically increase the PTD. Three single nucleotide polymorphisms (SNPs) in (rs6019, rs2213869 rs6022) were genotyped 542 mothers PTD 1,141 term deliveries at Boston Medical Center. The individual interactive effects SNPs on gestational age examined, respectively. results suggested smoking, three haplotype age. More importantly, we found significant interactions between two (rs6019 Compared non-smoking carrying rs6019 GG genotype, persistently genotypes GC or CC significantly (OR(95% CI): 2.1(1.2–3.6) for GC; 5.7(2.1–15.0) CC; p-interaction = 0.02). A interaction was also observed Similar pattern rs6022 In summary, our data indicated
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