Radial porous SiO 2 nanoflowers potentiate the effect of antigen/adjuvant in antitumor immunotherapy
作者： Yanjun Jiang , Jing Gao , Chuangnian Zhang , Xiaoli Wang , Ying Dong
DOI: 10.1007/S11705-020-2034-6
关键词:
摘要: Here, we reported a cancer nanovaccine based on SiO 2 nanoflowers with a special radial pore structure, which greatly enhanced cross-presentation and induced the production of cytotoxic T lymphocyte cells secreting granzymes B and interferon-γ. The antigen ovalbumin was covalently conjugated onto the as-synthesized hierarchical SiO 2 nanoflowers, and the adjuvant cytosine-phosphate-guanine was electrostatically adsorbed into their radial pore by simple mixing before use. The nanovaccine exhibited excellent storage stability without …
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