Metformin therapy during puberty delays menarche, prolongs pubertal growth, and augments adult height: a randomized study in low-birth-weight girls with early-normal onset of puberty.

摘要: Context and Objective: Low-birth-weight (LBW) girls who enter puberty earlier (around 8–9 yr) tend to have menarche, growth arrest, a shorter adult stature. At present, there is no therapy for most of these girls. In LBW with early puberty, hyperinsulinemic insulin resistance could underpin their rapid transit through loss We explored the effects sensitization metformin during puberty. Setting, Design, Patients: an open-labeled, prospective study, 22 (birth weight < −1.5 sd score gestational age) early-normal (stage 2 breast development at age were randomized remain untreated (n = 12) or receive (850 mg/d; n 10) 36 months (mean start, 9.0 yr). All remained between 42 months. Main Outcome Measures: Pubertal growth, body composition by absorptiometry, uterine-ovarian size ultrasound, fasting insulin, glucose, lipids, leptin, IGF-I, and...