Novel sEH Inhibitors and their Use
作者： Reema K. Thalji , Joseph Paul Marino , Yun Ding
DOI:
关键词:
摘要: The invention is directed to novel sEH inhibitors and their use in the treatment of diseases mediated by enzyme. Specifically, compounds according Formula I: wherein R1, R2, R4, R5, R6, A, B, Y, Z, n, m are defined below, pharmaceutically-acceptable salts thereof. can be used enzyme, such as hypertension. Accordingly, further pharmaceutical compositions comprising a compound invention. still methods inhibiting conditions associated therewith using or composition
lens.org参考文章(25)
Eve M. Taylor, Use of 9-substituted purine analogues and other molecules to stimulate neurogenesis ,(2001)
Fariba Soleymanzadeh, Alan David Swinamer, Jennifer A. Kowalski, Steven John Taylor, Ingo Andreas Mugge, Lombaert Stephane De, Anne Bettina Eldrup, Soluble Epoxide Hydrolase Inhibitors and Methods of Using Same ,(2007)
Yakov Rotshteyn, Kathleen P. Provoncha, Glen A. Coburn, Amy Qi Han, Triazines and related compounds having antiviral activity, compositions and methods thereof ,(2008)
Tsuyoshi Busujima, Graeme Semple, Katsunori Omodera, Yoshinori Sekiguchi, Martin Casper, Bryan A. Kramer, Ning Zou, Thuy-Anh Tran, Sangdon Han, Kosuke Kanuma, Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof ,(2004)
Dominick Anthony Quagliato, William Ronald Solvibile, Albert John Molinari, Mark Anthony Ashwell, Heterocyclic beta-3 adrenergic receptor agonists ,(2001)
Robert W. Dugger, Resolution of (R)-2-benzylsuccinic acid 4-[4-(N-t-butoxycarbonylmethylamino)-piperidine] amide ,(1993)
John R. Proudfoot, Richard H. Ingraham, Methods of using soluble epoxide hydrolase inhibitors ,(2002)
Alvin J. Glasky, Jack Diamond, Methods for treatment of disease-induced peripheral neuropathy and related conditions ,(2001)
Shinobu Mochizuki, Akira Miyake, Kiyoshi Yahiro, Kazuhiro Nakatou, Masanori Miura, Eiichi Nakai, Takeshi Suzuki, Hideki Kubota, 2,4,6-triamino-1,3,5-triazine derivative ,(2003)
Esther Martinborough, Nicole Zimmerman, Jesus E. Gonzalez, Dean Mitchell Wilson, Timothy Donald Neubert, Andreas Peter Termin, Pyrimidines useful as modulators of voltage-gated ion channels ,(2004)